Blatant Why

Open-source protein design agent for Claude Code

Commercial platforms wrap open-source tools behind paywalls and call it a revolution.
BY gives you direct access through Claude Code. No platform fees. Your tools, your compute, your designs.

_{Source: trust us bro}

Quick Start (5 minutes)

You don't need to be a developer. If you can open a terminal and paste commands, you can run BY.

1. Install prerequisites

2. Create your project

mkdir my-campaign && cd my-campaign
npx blatant-why init

This scaffolds everything: 11 MCP servers, 16 agents, 14 skills, 11 slash commands, and a CLAUDE.md orchestration file. Takes about 30 seconds.

3. Add your API key

cp .env.example .env
# Open .env and add your Tamarind key (see Compute Setup below)

4. Start designing

claude

Then just tell it what you want:

> "Design VHH nanobodies against PD-L1"

Or use the guided workflow:

> /by:plan-campaign

Or if it's your first time:

> /by:welcome

That's it. Claude Code handles the rest -- research, design, screening, and ranking.

What It Does

Give it a target protein. It researches across PDB, UniProt, and SAbDab. It plans a design campaign. It submits compute jobs to Tamarind Bio (free tier, no GPU required). It screens every design for structural quality, sequence liabilities, and developability. It ranks candidates by composite score. You get a table of lab-ready binders.

The whole pipeline runs inside Claude Code. No platform. No dashboard. No vendor lock-in.

What's Inside