Is io.github.Arielbs/rosetta-mcp-server safe to use?

io.github.Arielbs/rosetta-mcp-server has no known CVEs as of the latest MCPpedia security scan. Authentication requirements were not detected automatically - check the project's documentation before connecting in a shared environment.

How do I install io.github.Arielbs/rosetta-mcp-server?

io.github.Arielbs/rosetta-mcp-server supports copy-paste install configs on its MCPpedia page for Claude Desktop, Cursor, and Claude Code. Scroll to the Quick Install section and select your client.

What AI clients work with io.github.Arielbs/rosetta-mcp-server?

io.github.Arielbs/rosetta-mcp-server is compatible with claude-desktop, cursor, claude-code. It uses stdio and sse and http transport.

Is io.github.Arielbs/rosetta-mcp-server actively maintained?

io.github.Arielbs/rosetta-mcp-server is less actively maintained - last commit was 221 days ago.

io.github.Arielbs/rosetta-mcp-server

rosetta-mcp-server

Rosetta/PyRosetta protein modeling and Biotite translation for computational biology

88/wk GitHub npm PyPI

No known CVEs

No license

Stale

Last commit 221d ago

Works with most clients

Transport: stdio, sse, http

0 tools

Grade F

MCPpedia last refreshed this data 2d ago

Edit this pageView history

io.github.Arielbs/rosetta-mcp-server is an MCP server that Rosetta/PyRosetta protein modeling and Biotite translation for computational biology. Its tool list has not been published yet over stdio, sse and http, requires no API key, and scores 45/100 on MCPpedia's security, maintenance and efficiency rubric.

Health AI / ML

Step 1

Install in your client

Config is the same across clients - only the file and path differ.

Supported in Claude Desktopstdio, sse, http · Node 18+

Paste into ~/Library/Application Support/Claude/claude_desktop_config.json

{
  "mcpServers": {
    "rosetta": {
      "env": {
        "PYTHON_BIN": "/path/to/.venvs/rosetta-mcp/bin/python",
        "ROSETTA_BIN": "/path/to/rosetta_scripts.default.macosclangrelease"
      },
      "command": "rosetta-mcp-server"
    }
  }
}

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[![MCPpedia Score](https://mcppedia.org/api/badge/io-github-arielbs-rosetta-mcp-server)](https://mcppedia.org/s/io-github-arielbs-rosetta-mcp-server)

Read me

What io.github.Arielbs/rosetta-mcp-server does

Rosetta/PyRosetta protein modeling and Biotite translation for computational biology

Test This Server

Run this in your terminal to verify the server starts. Then let us know if it worked - your result helps other developers.

npx -y 'rosetta-mcp-server' 2>&1 | head -1 && echo "✓ Server started successfully"

After testing, let us know if it worked:

Loading README…

Scored, not listed

Why this score

Five weighted categories - click any category to see the underlying evidence.

Score breakdown

45/100across 5 weighted dimensions

How we score →

0255075100

−55

Security

Maintenance

Efficiency

Documentation

Compatibility

Categoriesclick a row to see evidence

Security

OSV.dev

No known CVEs.

Checked rosetta-mcp-server against OSV.dev.

Community

Reviews

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Have you used this server?

Share your experience - it helps other developers decide.

How easy was setup?Did it work reliably?How was the documentation?

Frequently Asked Questions

Is io.github.Arielbs/rosetta-mcp-server safe to use?: io.github.Arielbs/rosetta-mcp-server has no known CVEs as of the latest MCPpedia security scan. Authentication requirements were not detected automatically - check the project's documentation before connecting in a shared environment.
How do I install io.github.Arielbs/rosetta-mcp-server?: io.github.Arielbs/rosetta-mcp-server supports copy-paste install configs on its MCPpedia page for Claude Desktop, Cursor, and Claude Code. Scroll to the Quick Install section and select your client.
What AI clients work with io.github.Arielbs/rosetta-mcp-server?: io.github.Arielbs/rosetta-mcp-server is compatible with claude-desktop, cursor, claude-code. It uses stdio and sse and http transport.
Is io.github.Arielbs/rosetta-mcp-server actively maintained?: io.github.Arielbs/rosetta-mcp-server is less actively maintained - last commit was 221 days ago.

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Health AI / ML

Step 1

Install in your client

Config is the same across clients - only the file and path differ.

Supported in Claude Desktopstdio, sse, http · Node 18+

Paste into ~/Library/Application Support/Claude/claude_desktop_config.json

{
  "mcpServers": {
    "rosetta": {
      "env": {
        "PYTHON_BIN": "/path/to/.venvs/rosetta-mcp/bin/python",
        "ROSETTA_BIN": "/path/to/rosetta_scripts.default.macosclangrelease"
      },
      "command": "rosetta-mcp-server"
    }
  }
}

Are you the author?

Add this badge to your README to show your security score and help users find safe servers.

Embed in your READMEAbout badges →

[![MCPpedia Score](https://mcppedia.org/api/badge/io-github-arielbs-rosetta-mcp-server)](https://mcppedia.org/s/io-github-arielbs-rosetta-mcp-server)

Read me

What io.github.Arielbs/rosetta-mcp-server does

Rosetta/PyRosetta protein modeling and Biotite translation for computational biology

Test This Server

Run this in your terminal to verify the server starts. Then let us know if it worked - your result helps other developers.

npx -y 'rosetta-mcp-server' 2>&1 | head -1 && echo "✓ Server started successfully"

After testing, let us know if it worked:

README

Rosetta MCP Server

Author: Ariel J. Ben-Sasson

A Model Context Protocol (MCP) server that lets Cursor (or any MCP client) work with Rosetta, PyRosetta, and Biotite: run RosettaScripts, validate XML protocols, translate between Rosetta and Biotite, score structures, and query documentation -- all from your AI coding assistant.

What's new in v1.3.0 (vs v1.1.8 on npm)

New: Biotite integration

rosetta_to_biotite -- Find the Biotite equivalent of any Rosetta function with working example code (21 mappings covering structure I/O, SASA, RMSD, superimposition, secondary structure, contacts, hydrogen bonds, B-factors, angles, and more)
biotite_to_rosetta -- Reverse lookup: find the Rosetta equivalent of a Biotite function
translate_rosetta_script_to_biotite -- Translate entire RosettaScripts XML or PyRosetta code to Biotite Python. Design/optimization operations are flagged as Rosetta-only.
Fuzzy search with keyword aliases ("contacts", "binding energy", "surface area", "align", etc.)

Improved: XML to PyRosetta translator

37 element types supported (was 6): 11 movers, 9 filters, 10 selectors, 7 task operations
Full attribute handling: repeats, disable_design, cartesian, tolerance, threshold, distance, and more
Child element support: MoveMap (with Span), Reweight, ScoreFunction
Reports unrecognized elements so you know what needs manual work

Improved: Help and documentation

get_rosetta_help now accepts any topic: movers by name ("FastRelax"), concepts ("constraints", "docking"), or score functions ("ref2015") -- auto-fetches live docs from rosettacommons.org
search_rosetta_web_docs fallback: when DuckDuckGo is rate-limited, probes direct Rosetta docs URLs
get_cached_docs auto-caches: no need to call cache_cli_docs first
Expanded static help for score_functions, movers, filters, xml, and parameters

Improved: Scoring

pyrosetta_score: new per_residue option returns per-residue energy breakdown
scorefxn parameter now works (was ignored in v1.1.8)
Proper error messages for missing files instead of silent {}

Improved: Validation

validate_xml: new validate_against_schema option checks element names against the Rosetta XSD schema (catches typos like FastRleax)

MCP spec compliance fixes

tools/call responses now use correct { content: [{ type: "text", text }] } format
Tool errors return isError: true (not JSON-RPC errors)
Standard JSON-RPC error codes (-32601, -32700, -32603)
Removed false resources capability advertisement

Security fixes

User input no longer interpolated into Python code (uses env vars / stdin)
Temp files written to os.tmpdir() (not module directory)

Cleanup

Removed 3 redundant tools: list_functions (merged into get_rosetta_info), search_pyrosetta_wheels, cache_cli_docs (auto-cache in get_cached_docs)
Removed hardcoded personal paths
Fixed shadowed variables, async anti-patterns, dead code
18 tools (was 21), all with improved agent-oriented descriptions

Example: asking a naive question

This is what makes the MCP server powerful -- an AI agent can answer domain questions by calling the right tools automatically:

User asks in Cursor: "How do I relax my protein and what's the Biotite equivalent?"

The agent calls two MCP tools behind the scenes:

1. get_rosetta_help("FastRelax") returns 6000+ chars of live documentation:

FastRelax performs all-atom relaxation using the FastRelax protocol. Parameters include scorefxn, repeats, cartesian, disable_design, MoveMap configuration...

2. rosetta_to_biotite("FastRelax") returns:

{
  "found": true,
  "results": [{
    "rosetta": { "name": "FastRelax", "example": ["relax = FastRelax()", "relax.set_scorefxn(get_score_function('ref

... [View full README on GitHub](https://github.com/Arielbs/rosetta-mcp-server#readme)

Loading README…

Scored, not listed

Why this score

Five weighted categories - click any category to see the underlying evidence.

Score breakdown

45/100across 5 weighted dimensions

How we score →

0255075100

−55

Security

Maintenance

Efficiency

Documentation

Compatibility

Categoriesclick a row to see evidence

Security

OSV.dev

No known CVEs.

Checked rosetta-mcp-server against OSV.dev.

Community

Reviews

Be the first to review

Have you used this server?

Share your experience - it helps other developers decide.

How easy was setup?Did it work reliably?How was the documentation?

Frequently Asked Questions

Is io.github.Arielbs/rosetta-mcp-server safe to use?: io.github.Arielbs/rosetta-mcp-server has no known CVEs as of the latest MCPpedia security scan. Authentication requirements were not detected automatically - check the project's documentation before connecting in a shared environment.
How do I install io.github.Arielbs/rosetta-mcp-server?: io.github.Arielbs/rosetta-mcp-server supports copy-paste install configs on its MCPpedia page for Claude Desktop, Cursor, and Claude Code. Scroll to the Quick Install section and select your client.
What AI clients work with io.github.Arielbs/rosetta-mcp-server?: io.github.Arielbs/rosetta-mcp-server is compatible with claude-desktop, cursor, claude-code. It uses stdio and sse and http transport.
Is io.github.Arielbs/rosetta-mcp-server actively maintained?: io.github.Arielbs/rosetta-mcp-server is less actively maintained - last commit was 221 days ago.