Precision Medicine MCP Platform: A set of bioinformatics servers + tools - production multiomics/genomics + spatial transcriptomics. Example and demo for ovarian cancer
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Precision Medicine MCP is an MCP server that precision Medicine MCP Platform: A set of bioinformatics servers + tools - production multiomics/genomics + spatial transcriptomics. Example and demo for ovarian cancer. Its tool list has not been published yet over sse and http, requires no API key, and scores 35/100 on MCPpedia's security, maintenance and efficiency rubric.
Config is the same across clients - only the file and path differ.
{
"mcpServers": {
"precision-medicine-mcp": {
"url": "<see-readme-for-url>"
}
}
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Dedicated to PatientOne -- a dear friend who passed from High-Grade Serous Ovarian Carcinoma in 2025.
No automated test available for this server. Check the GitHub README for setup instructions.
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Dedicated to PatientOne -- a dear friend who passed from High-Grade Serous Ovarian Carcinoma in 2025.
This platform automates multi-modal data processing for clinical decision support — all results require clinician review before any clinical action.
A patient can spend months moving between referrals, imaging, repeat evaluations, and denials without reaching a decision. Much of that motion starts at the workup — the test that would have settled the question was never ordered, or the finding that would have opened a door was never generated.
Standard oncology panels (BRCA1/2, HRD, tumor genomic) surface no immunotherapy or investigational hypotheses. Standard lipid panels and population genetic screens miss the tests most likely to change preventive management. Integrating genomics, spatial transcriptomics, imaging, and clinical data by hand is clinically impractical — the platform automates it.
This platform does not triage patients or route referrals. It makes the analysis behind a decision complete on the first pass, instead of spread across a sequence of visits.
| Where the loop starts | What the platform does | Evidence |
|---|---|---|
| The decisive test was never ordered | Reports what was not tested, and why it would change management | PAT003 — Lp(a), APOE, CAC flagged after a "normal" panel (detail) |
| A threshold closed the door | Re-checks eligibility against current labeling, not just the panel's cutoff | PAT002 — HRD 35 fell below the myChoice 42 cutoff; OlympiA labeling reopens it (detail) |
| No hypothesis was ever generated | Synthesizes genomic, spatial, immune, and perturbation data into investigational paths | PAT001 + PAT002 — 6 hypotheses standard workup did not reach (detail) |
| The decision can't survive review | Every result carries XAI metadata behind a clinician APPROVE/REVISE/REJECT gate, with an audit trail | Proof layers → |
| Every modality is another handoff | One orchestrated session replaces a multi-day relay across specialists | An estimated 40 hours → an estimated 2–5 hours (modeled) |
Fewer tests is also a result. A CAC score of 0 would support deferring statin therapy for PAT003. The same analysis that adds a test can remove one — the goal is the decision, not the volume of workup.
Scope of the claim. These are three synthetic patients analyzed end-to-end, not clinical outcomes. Time and cost figures are modeled and pending clinical validation. The platform's contribution is to the quality and completeness of the decision, not to the referral pathway around it.
The platform surfaces clinically actionable findings that standard workup cannot reach — 6 investigational hypotheses across 2 cancer types plus 3 preventive health evidence gaps, validated across three independent use cases:
| Use Case | Patient | Key Finding Missed by Standard Workup |
|---|---|---|
| HGSOC (Stage IV) | PAT001 | 3 investigational paths: neoantigen vaccine (RMPEAAPPV IC50 7.8 nM), NNMT/CAF inhibition, convergent checkpoint blockade |
| ER+ Breast Cancer | PAT002 | 3 investigational hypothes |